Our new study, published in Cell Reports, introduces an optimized platform for cell-type-specific protein tagging and secretome mapping, enabling researchers to trace circulating proteins back to their tissue and cellular origins. In collaboration with the Cohen and Loh laboratories, we applied this approach to adipose tissue, liver, and immune cells to uncover how intercellular communication networks are remodeled during fasting, inflammation, and obesity. The work also revealed previously undetectable low-abundance circulating factors, providing a powerful resource for studying metabolism, immunity, and disease.
Read more about the work in this amazing write-up by Rockefeller University: https://www.rockefeller.edu/news/39962-obesity-immunity-protein-tagging/
Vinogradova Lab 