Excited to see the final version of our manuscript out in Cell Chemical Biology. In this study, we investigate the mechanism of action of an immunosuppressive small-molecule electrophile, which targets a core splicing factor SF3B1!
We further leverage advanced chemical proteomic workflows to explore more broadly the largely untapped potential for targeting of splicing with cysteine-reactive covalent electrophiles.
https://www.sciencedirect.com/science/article/pii/S2451945624004458
Vinogradova Lab 